Samsung confirmed the drastic decision in a statement, saying: "We can confirm the report that Samsung has permanently discontinued the production of Galaxy Note 7."
This comes just hours after the company confirmed that it had halted sales of the Galaxy Note 7 and urged customers to stop using the device if they already have one.
The company has already recalled 2.5 million Note 7 handsets, and this move follows reports that replacement phones are also catching fire.
One of these involved Michael Lering of Kentucky, who woke up this weekend to find his bedroom filled with smoke and his replacement Galaxy Note 7 on fire. He was taken to hospital with acute bronchitis and smoke inhalation.
Another involved a new Note 7 fire catching fire in Houston, Texas. Daniel Franks was having lunch with his wife and daughter when a replacement handset caught fire on the table.
In a carefully worded statement released on Tuesday, Samsung advised customers to power off the device and seek a refund or exchange it for a different phone.
The statement added that Samsung and its global carrier and retail partners have stopped selling and exchanging Note 7 smartphones. This comes after UK carriers EE and Three confirmed on Monday that they had stopped swapping Galaxy Note 7s following US operators AT&T and T-Mobile.
"We are working with relevant regulatory bodies to investigate the recently reported cases involving the Galaxy Note 7," Samsung said.
"Because consumers’ safety remains our top priority, Samsung will ask all carrier and retail partners globally to stop sales and exchanges of the Galaxy Note 7 while the investigation is taking place.
"We remain committed to working diligently with appropriate regulatory authorities to take all necessary steps to resolve the situation.
"Consumers with an original Galaxy Note 7 or replacement Galaxy Note 7 should power down and stop using the device and take advantage of the remedies available."
Samsung's shares dropped 7.5 per cent on Tuesday following this latest move, the biggest daily percentage decline since 2008, wiping more than $18bn off the company's value. µ
It's an onomatopoeic week for Google
Hope that free lunch was delicious
It's like Bixby being terrible never happened
Notch to be outdone