SEAGATE JUST ANNOUNCED three big drives, one is the biggest out there, the other two play catch-up. They now have the crown with a 1.5TB drive, and are going to be up with everyone else when the 500Gb 2.5-inch models come out.
The most impressive one is the 1.5TB Barracuda 7200.11, the 11th generation workhorse drive for people who download far too much content. It is a 4 platter model that claims a 120MBps data transfer rate. There are 16 and 32M cache versions, both will be on sale, along with smaller 7200.11 variants, this August. We inch closer to 'big enough'.
The difference between the reigning champ of HDs, the 1TB monsters of yesteryear and the new 1.5TB is of course 500GB. That is coincidently the same size as the new Seagate Momentus 5400.6 and 7200.4 The 5400.6 starts out at 120GB with an 8M cache, the 7200.4 at 250GB with 16M, and come in various sizes from there.
Both 2.5-inch lines have G-force sensors to detect falls and park the heads before they put divots on the platters. They say both will survive 1000Gs of non-operating, 350 operating, shock, so you could probably play tennis with them and not lose data. If anyone tries this, send us the videos, please.
The 2.5-inch drives will be out sometime in Q4, with no prices set as of yet. It looks like the HD bar has been raised once again. ยต
I can't wait for the hilarity that will result when the h4rdc0r3 gamers RAID0 these on their crappy little onboard controllers and find out the BIOS refuses to boot off a volume > 2GB, and no a partition will not solve it. :)
Actually i hav ethe GA-X48-DQ6 motherboard with 4x1TB seagate drives and raid-0, all run off the onboard raid controller.

Windows vista ultimate 64-bit runs flawlessly on a 4TB single ntfs partition.
If you have an EFI Bios you can boot from a GPT Volume/Disk. Using Vista SP1 or Some of the server variants. However there very limited options for PC motherboards with EFI compatibility and you'll have to bug support to get it too as those bioses are typically in beta or experimental state and unpublished.

Or you can buy an intel based Mac.

Please note: If you boot off a non-GPT disk 
(<2TB) many windows variants can read and write to GPT disks as a non-boot volume.