Prosecutors claim Troy Victorino, 29, Robert Cannon and Michael Salas, both 20, and Jerone Hunter, 19, organised the violent attack to retrieve an Xbox that Victorino lost when he was kicked out of a house in Deltona, Florida.
Some of the victims were killed in their sleep while others were said to be unable to resist the attack, which took place in August 2004.
Cannon previously admitted the charge and will receive life in prison in exchange for his testimony. Prosecutors are seeking the death penalty for the others.
The victims all worked at the local Burger King and had been terrorised for some days before the attack over the XBox, prosecutors say.
The Xbox had been left by Victorino at a Deltona squat and was subsequntly taken by one of the victims.
Prosecutor Leah Case said the death penalty would be "an appropriate punishment" for such a heinous crime.
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