A Few Scenarios

One use that immediately came to my mind was a media PC. Set a PC with this motherboard up near your TV and have one jack connected to your router and 3 connected to various PCs/Laptops.

This allows your PCs/Laptops to connect to to a web through a wireless router yet still maintain a wired connection to the media PC. Any scenario where you can throw out additional hardware and power adapters (such as a switch) or avoid running wires up/down some stairs is a good one.

Sharing a networked printer just became easier, and everyone knows the wireless adapter for the Xbox 360 is a rip off at $100.

The option is nice to have, but I wouldn't pay a premium for 4 ports over 2. 1 is usually more than I need, but I do find 2 to provide practical flexibility.

But if it means I can build a box, grab a network printer, buy a network attached storage box, run only 1 wire through the wall up to my router, and still have one port open in case someone with a laptop needs to transfer stuff quickly, that's great.

I wouldn't mind

I'd probably use it as a central media/data hub on my home network. would be interesting to play with at any rate. I quite like the 8 USB ports too. Not that I would ever use 8 but we all know how tight some of those darling little USB appliances can be so the option of spacing is nice. Better than the usual round of legacy connectors they stick on the back to fill out the I/O plate anyway.

VMware

vmware virtual infrastructure likes lots of dedicated nics for the management and drs features , so would be handy. is the chipset actually beefy enough to push that IO